Because of its function, it has been widely researched for its possible role in the treatment of a degenerative disease called osteoarthritis, and sure enough, scientists have found it to contain properties that may help reduce the symptoms of the disease. Others even claim that it can stop the progression and can eliminate the symptoms entirely. But in contradiction to these claims the British Medical Journal has voted against its efficacy as an osteoarthritis treatment basing from its comprehensive review.
However, many still use this non-vitamin non-mineral supplement in the form that uses a partner agent called Glucosamine. This substance is an amino sugar and is the precursor for glycosaminoglycans, the group of chemicals which Chondroitin belongs to. Its use as a separate supplement has been deemed safe in the prevention of cartilage degeneration and arthritis treatment. But like Chondroitin, there's conflicting evidence in its efficacy as a treatment for osteoarthritis. But clinical studies show that their separate effects are increased when administered in conjunction with each other.
Most of the Chondroitin and Glucosamine supplements today are derived from bovine products, specifically the trachea. Other known sources for these substances are pork by-products, shell fish, salmon, and shark. They can also be produced synthetically in a laboratory setting. They come in the form of capsules, tablets, and even powder. It is taken orally with a total daily dose that ranges from 800 mg to 1,200 mg taken two to four times a day. You must allow a month or so for the effects to present themselves. The therapy is done for six to twenty-four months. Effects beyond that period are unclear.
The exact mechanism of action of this supplement is unknown. But the combined substances (Chondroitin and Glucosamine) are believed to enhance the ability of collagen to absorb shock brought about by constant movement and the weight of the body. They are also believed to block the enzymes that deteriorate the structure and functioning of the cartilage. These substances may also help in water retention in the joints thereby reversing cartilage loss.
Reports of significant lessening of inflammation and pain are often heard from subjects who have taken part in clinical studies in relation to the effect of the supplement. Some of them have even decreased the dosage of their NSAIDs, which is the conventional treatment for osteoarthritis. Joint function can also be significantly improved, along with greater mobility and range of motion without the restrictive pain that accompanies each purposeful movement (except for severe cases that have already developed contractures).
